Regional Prospective Observational Research for Tuberculosis

RePORT India is charged with advancing regional TB science in India, towards fulfilling the TB strategic goals of the country, strengthening TB research capacity and infrastructure and fostering research collaboration within India and with other countries focused on research that can lead to clinically important biomarkers, vaccines, drugs, and diagnostics.

Collaborative Governance Structure

1

Executive Committee

An Executive Committee led by four Chairs and PIs from participating institutions across India and the U.S.

2

Coordinating Hub

India Co-Hub housed at JIPMER and U.S. Co-Hub housed at JHU, a Data Coordination Centre housed at JIPMER

3

Scientific Groups

Three Scientific Working Groups (Basic Science, Clinical Epidemiology, Behavioral Science)

4

Operational Groups

Five Operational Working Groups (Common Protocol Leadership, Study Coordination, Publication Committee, Laboratory Management, and Data Management)

5

Central Biorepository

A Central Biorepository housed at NIRT in Thiruvallur Campus

EC Chairs

Amita Gupta

Amita Gupta

JHU | EC Chair, USA

Sonali Sarkar

Sonali Sarkar

JIPMER | EC Chair, India

Padmini Salgame

Padmini Salgame

RUTGERS | EC Co-Chair, USA

Vijaya Lakshmi Valluri

Vijaya Lakshmi Valluri

BMMRC | EC Co-Chair, India

RePORT India Coordinating Hub

India Co-Hub

Puducherry, India

The purpose of the Coordinating Hub is to provide administrative and operational support to the consortium. The India-based Co-Hub is housed at JIPMER in Puducherry, where the India EC Chair oversees the RePORT India Program Manager, Administrative Coordinator, and Data Coordination Centre. The India-based Co-Hub is dedicated to coordinating activities across Indian Clinical Research Sites and liaising with DBT, India.

U.S. Co-Hub

Baltimore, USA

The U.S.-based Co-Hub is housed at JHU in Baltimore, where the U.S. Chair oversees a U.S.-based Program Manager, Communication Specialist, and Finance Manager. The U.S. based Co-Hub is dedicated to supporting the India Co-Hub, coordinating activities across U.S. participating institutions, as well as liaising with NIH/DAIDS and CRDF Global.

Central Biorepository

Thiruvallur, India

The RePORT India Central Biorepository recently transitioned to ICMR-NIRT’s newly constructed Composite Research Facility at its Thiruvallur site ~50km away from the main campus. A fully equipped BSL-III laboratory, animal BSL-III laboratory, and Data Centre are annexed to this facility to facilitate cutting edge TB research.

Participating Institutions

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Latest Developments in TB Science

Oxford University Press

Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection – a Multicenter Prospective Cohort Analysis

report india contributes to public health

India’s National Tuberculosis Elimination Programme (NTEP) just doubled cash transfers for all persons with TB, introduced nutritional support for undernourished PWTB, and significantly expanded nutritional support expectations in the Nikshay Mitra program. This represents a welcome person-centered response by the Indian government in response to emerging research that included studies from the RePORT India consortium that demonstrated the impact of undernutrition on TB mortality, the increased risk of TB progression among undernourished household contacts, and the cost-effectiveness of nutritional interventions to reduce TB incidence and mortality. 

Listed below are links to papers that are specific to nutrition studies in RePORT.

Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis

Undernutrition and Tuberculosis: Public Health Implications

Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection – a Multicenter Prospective Cohort Analysis

Nutritional Supplementation Would Be Cost-Effective for Reducing Tuberculosis Incidence and Mortality in India: The Ration Optimization to Impede Tuberculosis (ROTI-TB) Model